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Comment
. 2013 Nov;21(11):1981-3.
doi: 10.1038/mt.2013.227.

Enhanced oncolytic virotherapy through oxidative stress inhibition

Kendra L Congdon  1 , John H Sampson
Affiliations
Comment

Enhanced oncolytic virotherapy through oxidative stress inhibition

Kendra L Congdon et al. Mol Ther. 2013 Nov.
No abstract available

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Figures

Figure 1
Figure 1
The antioxidant N-acetylcysteine amide (NACA) reduces oxidative stress within CRAd-S-pk7 infected neural stem cells to enhance oncolytic virotherapy of glioma. Glioma-tropic neural stem cells (NSCs) are infected with oncolytic virus (CRAd-S-pk7) and used as carriers for viral delivery to the tumor. Cell carriers in oncolytic virotherapy (OV) can protect virus from host immune-mediated clearance and permit viral replication to boost titers, resulting in improved viral delivery and intratumoral spread. However, infection triggers reactive oxygen species (ROS) in NSCs, with consequent expression of proapoptotic proteins and signaling pathways associated with oxidative stress. NACA reduces ROS within NSCs, with consequent increases in NSC viability, viral release, intratumoral viral spread, and enhanced median survival in a preclinical model of orthotopic glioma. Thus, oxidative stress has been identified as a novel therapeutic target in cell carrier–mediated OV.
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