doi: 10.1007/BF01310892.
Molecular hybridization studies with scrapie brain nucleic acids. II. Differential expression in scrapie hamster brain
- PMID: 2420312
- DOI: 10.1007/BF01310892
Item in Clipboard
Molecular hybridization studies with scrapie brain nucleic acids. II. Differential expression in scrapie hamster brain
Arch Virol.
1986.
Abstract
RNA and DNA fractions prepared from nucleic acids obtained from normal and scrapie-infected hamster brains following exhaustive treatment with nuclease were used as probes in a search for a specific scrapie nucleic acid. Employing RNA blot hybridization a 2.3 Kb RNA was detected in higher concentration in scrapie-infected hamster brains than in normal controls. Our data suggests that scrapie disease may be associated with the differential expression of a series of host genes.
Similar articles
-
Molecular hybridization studies with scrapie brain nucleic acids. I. Search for specific DNA sequences.Arch Virol. 1986;88(1-2):67-78. doi: 10.1007/BF01310891. Arch Virol. 1986. PMID: 3082311
-
Molecular cloning of single-stranded DNA purified from scrapie-infected hamster brain.Res Virol. 1993 Sep-Oct;144(5):375-87. doi: 10.1016/s0923-2516(06)80053-1. Res Virol. 1993. PMID: 8284515
-
Search for scrapie-specific RNA and attempts to detect an infectious DNA or RNA.J Gen Virol. 1976 Aug;32(2):157-62. doi: 10.1099/0022-1317-32-2-157. J Gen Virol. 1976. PMID: 828199
-
The search for scrapie agent nucleic acid.Microbiol Rev. 1990 Sep;54(3):242-6. doi: 10.1128/mr.54.3.242-246.1990. Microbiol Rev. 1990. PMID: 2120561 Free PMC article. Review.
-
Search for a scrapie-specific nucleic acid: a progress report.Ciba Found Symp. 1988;135:209-23. doi: 10.1002/9780470513613.ch14. Ciba Found Symp. 1988. PMID: 3137001 Review.
Cited by
-
The molecular mechanisms of scrapie encephalopathy and relevance to human neurodegenerative disease.Can J Vet Res. 1990 Jan;54(1):49-57. Can J Vet Res. 1990. PMID: 2407330 Free PMC article. Review.
-
Conservation of infectivity in purified fibrillary extracts of scrapie-infected hamster brain after sequential enzymatic digestion or polyacrylamide gel electrophoresis.Proc Natl Acad Sci U S A. 1990 Sep;87(18):7240-4. doi: 10.1073/pnas.87.18.7240. Proc Natl Acad Sci U S A. 1990. PMID: 2119503 Free PMC article.