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. 1986 Feb 26;135(1):297-303.
doi: 10.1016/0006-291x(86)90976-9.

Isolation and characterization of a carcinoma-associated antigen

A H Ross, D Herlyn, D Iliopoulos, H Koprowski

Isolation and characterization of a carcinoma-associated antigen

A H Ross et al. Biochem Biophys Res Commun. .

Abstract

GA733 is a murine IgG2a monoclonal antibody (MAb) against human gastric carcinoma and is highly tumoricidal in nude mice. The GA733 antigen is a cell surface protein with two subunits of 30,000 and 40,000 daltons. The antigen isolated by immunoaffinity chromatography consists mainly of the 30,000-dalton subunit which bears the GA733 epitope. This subunit displayed several isoelectric points between 6.9 and 7.7. Anti-colon carcinoma MAb 17-1A also detects this antigen, but probably binds to a different epitope.

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