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. 2014 Jan;45(1):268-70.
doi: 10.1161/STROKEAHA.113.003003. Epub 2013 Nov 7.

Incidence of oral anticoagulant-associated intracerebral hemorrhage in the Netherlands

Angel M R Schols  1 , Floris H B M Schreuder, Elisabeth P M van Raak, Tobien H C M L Schreuder, Fergus A Rooyer, Robert J van Oostenbrugge, Julie Staals
Affiliations

Incidence of oral anticoagulant-associated intracerebral hemorrhage in the Netherlands

Angel M R Schols et al. Stroke. 2014 Jan.

Abstract

Background and purpose: The aim of this study was to estimate the annual adult incidence and risk of intracerebral hemorrhage (ICH) and oral anticoagulant-associated ICH (OAC-ICH) in the Netherlands.

Methods: We retrospectively selected all consecutive adult patients with a nontraumatic ICH seen in 1 of 3 hospitals in the region South-Limburg, the Netherlands, from 2007 to 2009. Crude incidences were age-adjusted to Dutch and European population.

Results: We identified 652 ICH cases, of which 168 (25.8%) were OAC associated. The adult Dutch age-adjusted annual incidence of ICH and OAC-ICH was 34.8 (95% confidence interval, 32.0-37.8) and 8.7 (95% confidence interval, 7.3-10.3) per 100 000 person-years, respectively. The absolute risk of OAC-ICH was estimated at 0.46% per patient-year of OAC treatment.

Conclusions: The annual incidences of ICH and OAC-ICH are relatively high in the Netherlands when compared with international literature.

Keywords: anticoagulants; cerebral hemorrhage; epidemiology; incidence.

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