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. 2013:8:1467-70.
doi: 10.2147/CIA.S47350. Epub 2013 Oct 31.

Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma

Ying Hu  1 , Hai Bo Tan, Xin Mei Wang, Hua Rong, Hong Ping Cui, Hao Cui
Affiliations

Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma

Ying Hu et al. Clin Interv Aging. 2013.

Abstract

Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma.

Keywords: aging; cell therapy; glaucoma; stem cell; transplantation.

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Figures

Figure 1
Figure 1
Design of the visual water box for behavior testing. The box was divided into three parts, ie, a swimming box and two decision chambers. A computer screen at the end of each decision chamber was used to present visual cues. In the right decision chamber, there was a hidden platform as the end point of the swimming test.
Figure 2
Figure 2
Fluorogold® counting of surviving retinal ganglion cells. (A) Control group, (B) surgery group, (C) low transplant group, and (D) high transplant group.
Figure 3
Figure 3
Results for visual water box swimming test, showing that the surgery group had a much slower response (longer latency to hidden platform) and that cell transplantation partly rescued this behavior. Note: *indicates 0.05; **indicates 0.01.
See this image and copyright information in PMC

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