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Review
. 2013 Dec;93(6):1451-66.
doi: 10.1016/j.suc.2013.08.002. Epub 2013 Sep 29.

Management of antibody-mediated rejection in transplantation

Basma Sadaka  1 , Rita R Alloway, E Steve Woodle
Affiliations
Review

Management of antibody-mediated rejection in transplantation

Basma Sadaka et al. Surg Clin North Am. 2013 Dec.

Abstract

Despite intensive traditional immunosuppressive therapy, rates of graft loss have approximated 15% to 20% at 1 year following antibody-mediated rejection (AMR) in solid organ transplant recipients. Therefore, the development of antihumoral therapies that provide prompt elimination of donor-specific anti-HLA antibodies and improve allograft survival is an important goal. Traditional treatment modalities for AMR deplete B-cell populations but not the cell at the source of antibody production, the mature plasma cell. Plasma cell-targeted therapies using proteasome inhibition is a novel approach to treating AMR. This review discusses current and emerging treatment modalities used for AMR.

Keywords: Antibody-mediated rejection; Donor-specific antibodies; Kidney transplantation; Plasma cell.

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