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Comment
. 2013 Nov 7;13(5):514-6.
doi: 10.1016/j.stem.2013.10.012.

A new image of the hematopoietic stem cell vascular niche

Leslie E Silberstein  1 , Charles P Lin
Affiliations
Comment

A new image of the hematopoietic stem cell vascular niche

Leslie E Silberstein et al. Cell Stem Cell. .

Abstract

The microenvironment within the bone marrow that maintains hematopoietic stem cell (HSC) quiescence is the subject of intense study. In a recent Nature paper, Kunisaki et al. combine imaging techniques and computational modeling to define a novel arteriolar niche for quiescent HSCs within the bone marrow.

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Figures

Figure 1
Figure 1
The prevailing view of the hematopoietic stem cell niche in the bone marrow, with HSCs residing close to either the vasculature or the endosteal surface (left).. Kunisaki et al. demonstrate the co-existence of multiple vasculature niches in the bone marrow, with the arteriolar niche maintaning quiescent HSCs while the sinusoidal niche supports cuycling HSCs (right).
See this image and copyright information in PMC

Comment on

  • Arteriolar niches maintain haematopoietic stem cell quiescence.
    Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, Mizoguchi T, Wei Q, Lucas D, Ito K, Mar JC, Bergman A, Frenette PS. Kunisaki Y, et al. Nature. 2013 Oct 31;502(7473):637-43. doi: 10.1038/nature12612. Epub 2013 Oct 9. Nature. 2013. PMID: 24107994 Free PMC article.

References

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