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. 2013 Sep-Oct;21(5):416-21.
doi: 10.1590/1679-775720130206.

Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma

Camila Santos Pereira  1 , Marcos Vinícius Macedo de Oliveira, Lucas Oliveira Barros, Gabriela Alencar Bandeira, Sérgio Henrique Sousa Santos, John R Basile, André Luiz Sena Guimarães, Alfredo Maurício Batista De Paula
Affiliations

Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma

Camila Santos Pereira et al. J Appl Oral Sci. 2013 Sep-Oct.

Abstract

Objective: This study aimed to investigate the expression of the MSH2 DNA repair protein in head and neck squamous cell carcinoma (HNSCC) in order to analyze its association with clinicopathologic factors and overall survival of patients.

Material and methods: Clinical data and primary lesions of HNSSC were collected from 55 patients who underwent surgical resection with postoperative radiotherapy in Montes Claros, state of Minas Gerais, Brazil, between 2000 and 2008. Immunohistochemical reactions were performed to analyze MSH2 protein expression.

Results: Bivariate analysis showed no significant correlation or association between MSH2 expression and clinicopathologic parameters by Mann-Whitney and Kruskal-Wallis tests. Patients with locoregional metastatic disease (OR=4.949, p<0.001) and lower MSH2 immunohistochemical expressions (OR=2.943, p=0.032) presented poorer survival for HNSCC by Cox regression models.

Conclusions: Our data demonstrated that lower MSH2 expression might contribute to a higher clinic aggressiveness of HNSCC by promoting an unfavorable outcome.

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Conflict of interest statement

Competing Interests: The authors declare no competing interests.

Figures

Figure 1
Figure 1
Immunohistochemical expression of MSH2 repair protein in healthy oral mucosa and carcinoma cells of the invasive front of head and neck squamous cell carcinoma (HNSCC). A: Low immunohistochemical expression in basal layer of oral healthy epithelium. B/C: High immunohistochemical expression cases of HNSCC. Slides were stained with diaminobenzidine and counterstained with Mayer’s haematoxylin
Figure 2
Figure 2
Overall survival analysis in head and neck squamous cell carcinoma patients using Kaplan-Meier survival curves after 2704 days, according to locoregional metastatic disease (A) and MSH2 protein expression (B). Differences between groups were evaluated by the log-rank test
See this image and copyright information in PMC

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