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Review
. 2014 Jan;37(1):16-23.
doi: 10.1007/s12272-013-0286-0. Epub 2013 Nov 12.

Extracellular stability of nanoparticulate drug carriers

Karen C Liu  1 , Yoon Yeo
Affiliations
Review

Extracellular stability of nanoparticulate drug carriers

Karen C Liu et al. Arch Pharm Res. 2014 Jan.

Abstract

Nanoparticulate (NP) drug carrier systems are attractive vehicles for selective drug delivery to solid tumors. Ideally, NPs should evade clearance by the reticuloendothelial system while maintaining the ability to interact with tumor cells and facilitate cellular uptake. Great effort has been made to fulfill these design criteria, yielding various types of functionalized NPs. Another important consideration in NP design is the physical and functional stability during circulation, which, if ignored, can significantly undermine the promise of intelligently designed NP drug carriers. This commentary reviews several NP examples with stability issues and their consequences, ending in a discussion of experimental methods for reliable prediction of NP stability.

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Figures

Fig. 1
Fig. 1
Blood kinetics of 111In labeled TSLs containing doxorubicin. The percentage of the injected dose (%ID) is plotted per gram blood (left axis) and for the total blood (right axis). Reprinted with permission from (de Smet et al. 2011). Copyright © 2011 Elsevier
Fig. 2
Fig. 2
Viability of SKOV-3 cells exposed to PTX or PTX/NS at different pHs for 3 or 72 h. Reprinted with permission from (Amoozgar et al. 2012). Copyright © 2012 American Chemical Society
Fig. 3
Fig. 3
Fluorescence spectra of PEG-PDLLA FRET micelles diluted by ten times with a water and b acetone. Insets show diagram of a FRET micelle prepared with 0.75 %DiO and 0.75 %DiI at 2 mg/mL polymer concentration. c Fluorescence spectra of FRET micelles in blood vessels during 3 h post IV injection. Reprinted with permission from (Chen et al. 2008b). Copyright © 2008 American Chemical Society
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References

    1. Amoozgar Z, Park J, Lin Q, Yeo Y. Low molecularweight chitosan as a pH-sensitive stealth coating for tumorspecific drug delivery. Molecular Pharmaceutics. 2012;9:1262–1270. - PMC - PubMed
    1. Bajaj G, Kim MR, Mohammed SI, Yeo Y. Hyaluronic acid-based hydrogel for regional delivery of paclitaxel to intraperitoneal tumors. Journal of Controlled Release. 2012;158:386–392. - PMC - PubMed
    1. Burt HM, Zhang X, Toleikis P, Embree L, Hunter WL. Development of copolymers of poly(d, l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel. Colloids and Surfaces B. 1999;16:161–171.
    1. Chen H, Kim S, He W, Wang H, Low PS, Park K, Cheng J-X. Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo Förster resonance energy transfer imaging. Langmuir. 2008a;24:5213–5217. - PubMed
    1. Chen H, Kim S, Li L, Wang S, Park K, Cheng J-X. Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Forster resonance energy transfer imaging. Proceedings of the National Academy of Sciences. 2008b;105:6596–6601. - PMC - PubMed

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