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Review
. 2013 Nov;7 Suppl 3(Suppl 3):67-71.
doi: 10.1111/irv.12177.

Influenza encephalopathy and related neuropsychiatric syndromes

Masashi Mizuguchi  1
Affiliations
Review

Influenza encephalopathy and related neuropsychiatric syndromes

Masashi Mizuguchi. Influenza Other Respir Viruses. 2013 Nov.

Abstract

Influenza is occasionally complicated by CNS disorders, in particular impairment of consciousness. Severe disorders encompass multiple, distinct syndromes manifesting acute encephalopathy, whereas mild disorders represent multiple, ill-defined neuropsychiatric syndromes. Acute encephalopathy is manifested with seizures and coma, with or without multi-organ involvement. The outcome varies from death or neurologic sequelae to recovery and differs among syndromes. Transient neuropsychiatric disorders are manifested with delirium and/or abnormal behavior. There also are multiple syndromes. The outcome is usually favorable, although occasional fatal accidents warrant caution.

Keywords: Acute encephalopathy; coma; delirium; influenza; oseltamivir.

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Conflict of interest statement

The author has no competing interests to declare.

References

    1. Abe J, Koizumi Y, Kudo M et al Five cases of Reye‐like syndrome: acute encephalopathy with hypodensities in the bilateral thalamus and cerebellum on cranial CT, hypoproteinemia and hypolipidemia (abstract). J Jpn Pediatr Soc 1987; 91:514 (in Japanese).
    1. Togashi T, Furuta H, Matsuzono Y, Takeoka Y, Anakura M, Bagano N. Influenza‐associated encephalitis/encephalopathy in childhood. J Jpn Pediatr Soc 1999; 103:1202–1209 (in Japanese).
    1. Kasai T, Togashi T, Morishima T. Encephalopathy associated with influenza epidemics. Lancet 2000; 355:1558–1559. - PubMed
    1. Morishima T, Togashi T, Yokota S et al Encephalitis and encephalopathy associated with an influenza epidemic in Japan. Clin Infect Dis 2002; 35:512–517. - PubMed
    1. Okamoto E. Is oseltamivir (Tamiflu) safe? Re‐examining the Tamiflu ‘ado’ from Japan. Expert Rev Pharmacoecon Outcomes Res 2010; 10:17–24. - PubMed