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. 2014 Mar;25(3):163-77.
doi: 10.1177/0956462413491735. Epub 2013 Aug 29.

Incidence and progression of cervical lesions in women with HIV: a systematic global review

Sheri A Denslow  1 , Anne F Rositch, Cynthia Firnhaber, Jie Ting, Jennifer S Smith
Affiliations

Incidence and progression of cervical lesions in women with HIV: a systematic global review

Sheri A Denslow et al. Int J STD AIDS. 2014 Mar.

Abstract

Global data on cervical lesion incidence and progression in HIV-positive women are essential for understanding the natural history of cervical neoplasia and informing screening policy. A systematic review was performed summarizing the incidence and progression of cervical lesions in HIV-positive women. Of 5882 HIV-positive women from 15 studies, incidence ranged from 4.9 to 21.1 cases per 100 woman-years for any cervical lesion and 0.4 to 8.8 cases per 100 woman-years for high-grade cervical lesions. HIV-positive women showed a median three-fold higher incidence of cervical lesions compared to HIV-negative women. Of 1099 HIV-positive women from 11 studies, progression from low- to high-grade lesions ranged from 1.2 to 26.2 cases per 100 woman-years. Both incidence and progression rates increased with lower CD4 counts. The effect of antiretroviral therapy on the natural history of cervical neoplasia remains unclear. HIV-positive women have higher incidence and progression of cervical neoplasia. Cervical cancer screening should be integrated into HIV treatment programmes.

Keywords: AIDS; CIN; HIV; SIL; cervical cancer; cervical lesions; incidence; progression; review; screening; squamous epithelial lesions; women.

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Conflict of interest statement

Disclosure of interests:

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Incidence rates reported or calculated for LSIL (A) or HSIL (B) in HIV-positive women. Rates are reported as cases per 100 woman-years. Solid lines show unweighted mean rate. Dotted lines show 95% confidence intervals around the unweighted mean. *This study reports CIN2–3.
See this image and copyright information in PMC

References

    1. UNAIDS, WHO. AIDS Epidemic Update. 2009 Dec; http://data.unaids.org/pub/report/2009/jc1700_epi_update_2009_en.pdf.
    1. Scheurer ME, Tortolero-Luna G, KA-S Human papillomavirus infection: biology, epidemiology, and prevention. Int J Gynecol Cancer. 2005;15(5):727–746. - PubMed
    1. De Vuyst H, Lillo F, Broutet N, Smith JS. HIV, human papillomavirus, and cervical neoplasia and cancer in the era of highly active antiretroviral therapy. Eur J Cancer Prev. 2008;17(6):545–54. - PubMed
    1. Firnhaber C, Zungu K, Levin S, et al. Diverse and high prevalence of human papillomavirus associated with a significant high rate of cervical dysplasia in human immunodeficiency virus-infected women in Johannesburg, South Africa. Acta Cytol. 2009;53(1):10–7. - PMC - PubMed
    1. Ahdieh L, Munoz A, Vlahov D, Trimble CL, Timpson LA, Shah K. Cervical neoplasia and repeated positivity of human papillomavirus infection in human immunodeficiency virus-seropositive and -seronegative women. Am J Epidemiol. 2000;151(12):1148–57. - PubMed

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