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. 2013 May 24;5(2):591-616.
doi: 10.3390/cancers5020591.

Current therapeutic strategies and novel approaches in osteosarcoma

Kosei Ando  1 , Marie-Françoise Heymann, Verena Stresing, Kanji Mori, Françoise Rédini, Dominique Heymann
Affiliations

Current therapeutic strategies and novel approaches in osteosarcoma

Kosei Ando et al. Cancers (Basel). .

Abstract

Osteosarcoma is the most frequent malignant primary bone tumor and a main cause of cancer-related death in children and adolescents. Although long-term survival in localized osteosarcoma has improved to about 60% during the 1960s and 1970s, long-term survival in both localized and metastatic osteosarcoma has stagnated in the past several decades. Thus, current conventional therapy consists of multi-agent chemotherapy, surgery and radiation, which is not fully adequate for osteosarcoma treatment. Innovative drugs and approaches are needed to further improve outcome in osteosarcoma patients. This review describes the current management of osteosarcoma as well as potential new therapies.

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Figures

Figure 1
Figure 1
Five year overall survival of localized osteosarcoma (from Allison et al. [9]).
See this image and copyright information in PMC

References

    1. Meyers P.A., Gorlick R. Osteosarcoma. Pediatr. Clin. North Am. 1997;44:973–989. doi: 10.1016/S0031-3955(05)70540-X. - DOI - PubMed
    1. Dorfman H.D., Czerniak B. Bone cancers. Cancer. 1995;75:203–210. doi: 10.1002/1097-0142(19950101)75:1+<203::AID-CNCR2820751308>3.0.CO;2-V. - DOI - PubMed
    1. Stiller C.A. International patterns of cancer incidence in adolescents. Cancer Treat. Rev. 2007;33:631–645. doi: 10.1016/j.ctrv.2007.01.001. - DOI - PubMed
    1. Coventry M.B., Dahlin D.C. Osteogenic sarcoma—A critical analysis of 430 cases. J. Bone Joint Surg. Am. 1957;39:741–757. - PubMed
    1. Marcove R.C., Mike V., Hajek J.V., Levin A.G., Hutter R.V. Osteogenic sarcoma under the age of twenty-one—A review of one hundred and forty-five operative cases. J. Bone Joint Surg. Am. 1970;52:411–423. - PubMed