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Comparative Study
. 1986 Mar 26;369(1-2):400-4.
doi: 10.1016/0006-8993(86)90560-3.

Distribution of substance K (neurokinin A) in the brain and peripheral tissues of rats

Y Takano, A Nagashima, H Masui, K Kuromizu, H O Kamiya
Comparative Study

Distribution of substance K (neurokinin A) in the brain and peripheral tissues of rats

Y Takano et al. Brain Res. .

Abstract

The regional distribution of substance P (SP) and substance K (SK) in the central nervous system and peripheral tissues of rats was studied. High levels of SK-like immunoreactivity (SK-LI) and of SP-like immunoreactivity (SP-LI) were found in the substantia nigra, nucleus tractus solitarius and nucleus habenula. Neonatal treatment of rats with capsaicin caused a significant decrease in the SK-LI content in the submaxillary gland, but capsaicin had no effect on SK-LI content in any area of the brain. These observations suggest that SK in the brain and peripheral tissues may have significant physiological roles.

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