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. 2014 Feb;82(1):122-9.
doi: 10.1037/a0035046. Epub 2013 Nov 11.

Anhedonia, depressed mood, and smoking cessation outcome

Adam M Leventhal  1 , Megan E Piper  2 , Sandra J Japuntich  3 , Timothy B Baker  2 , Jessica W Cook  2
Affiliations

Anhedonia, depressed mood, and smoking cessation outcome

Adam M Leventhal et al. J Consult Clin Psychol. 2014 Feb.

Abstract

Objective: Although the relation between lifetime depression and smoking cessation outcome has been well studied, the proposition that different symptomatic expressions of depression exert disparate predictive effects on risk of smoking cessation failure has largely gone uninvestigated. This study analyzed the individual contributions of depression's 2 hallmark affective symptoms, anhedonia (i.e., diminished interest in normally enjoyable activities) and depressed mood (i.e., elevated sadness), to the prediction of smoking cessation outcome.

Method: Participants were adult daily smokers (N = 1,469; mean age = 45 years, 58% female, 84% White) enrolled in a smoking cessation treatment study. Lifetime history of anhedonia and depressed mood were classified via structured interview prior to quit day. Seven-day point prevalence smoking abstinence was assessed at 8 weeks and 6 months postquit.

Results: When examined separately, both lifetime anhedonia, OR (95% CI) = 1.42 (1.16, 1.73), p = .004, and depressed mood, OR (95% CI) = 1.35 (1.11, 1.63), p = .002, predicted increased odds of relapse. These relations remained after adjusting for covariates, including lifetime depressive disorder, which did not predict outcome. After controlling for the covariation between lifetime anhedonia and depressed mood, anhedonia predicted cessation outcome, OR (95% CI) = 1.31 (1.05, 1.62), p = .02, while depressed mood did not (p = .19). Symptom duration (>2 weeks), treatment, and substance use disorder did not modify relations of lifetime anhedonia and depressed mood with cessation outcome.

Conclusions: Results suggest that (1) symptoms of affective disturbance capture depression-relevant risk of cessation failure, which is not adequately demarcated by the lifetime depressive disorder diagnosis, and (2) anhedonia is a more sensitive index of this affective disturbance than depressed mood per se. Clinical attention to anhedonia may facilitate smoking cessation.

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Figures

Figure 1
Figure 1
Study flow diagram.
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References

    1. APA. Diagnostic and statistical manual of mental disorders (fourth edition) American Psychiatric Association; 1994.
    1. Baker TB, Piper ME, McCarthy DE, Majeskie MR, Fiore MC. Addiction motivation reformulated: an affective processing model of negative reinforcement. Psychological Review. 2004;111(1):33–51. doi: 10.1037/0033-295X.111.1.33. - DOI - PubMed
    1. Bolt DM, Piper ME, McCarthy DE, Japuntich SJ, Fiore MC, Smith SS, Baker TB. The Wisconsin Predicting Patients' Relapse questionnaire. Nicotine and Tobacco Research. 2009;11(5):481–492. doi: 10.1093/ntr/ntp030. - DOI - PMC - PubMed
    1. Breslau N, Peterson E, Schultz L, Andreski P, Chilcoat H. Are smokers with alcohol disorders less likely to quit? Am J Public Health. 1996;86(7):985–990. - PMC - PubMed
    1. Brown RA, Kahler CW, Niaura R, Abrams DB, Sales SD, Ramsey SE, Miller IW. Cognitive-behavioral treatment for depression in smoking cessation. Journal of consulting and clinical psychology. 2001;69(3):471–480. - PMC - PubMed

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