Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986;23(4):246-51.
doi: 10.1007/BF00373019.

Transfection of murine LMTK- cells with purified HLA class I genes. VII. Association of allele- and locus-specific serological reactivities with respectively the first and second domains of the HLA-B7 molecule

R Sodoyer, B Kahn-Perles, T Strachan, J Sire, M J Santoni, C Layet, P Ferrier, B R Jordan, F A Lemonnier

Transfection of murine LMTK- cells with purified HLA class I genes. VII. Association of allele- and locus-specific serological reactivities with respectively the first and second domains of the HLA-B7 molecule

R Sodoyer et al. Immunogenetics. 1986.

Abstract

The individual contributions of the first two external domains of the HLA-B7 heavy chain to the expression of allele-specific (B7) and locus-specific (B and C) antigenic determinants were investigated using hybrid class I genes. Hybrid genes were constructed in vitro by exon shuffling between the parent genes HLA-B7, HLA-Cw3, HLA-A3, and H-2Kd, and their expression was monitored following transfection into mouse L cells. The results show that most allele-specific antigenic determinants are associated with the first external domain of the B7 heavy chain, whereas all the locus-specific antigenic determinants tested map to the second external domain.

PubMed Disclaimer

References

    1. Cell. 1979 Apr;16(4):777-85 - PubMed
    1. J Biol Chem. 1985 Oct 5;260(22):11924-33 - PubMed
    1. J Immunol. 1982 Jun;128(6):2804-6 - PubMed
    1. EMBO J. 1984 Apr;3(4):887-94 - PubMed
    1. Hum Immunol. 1984 Sep;11(1):31-45 - PubMed

Publication types

LinkOut - more resources