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. 2013 Nov 18;52(47):12426-9.
doi: 10.1002/anie.201306098. Epub 2013 Sep 25.

Indole synthesis by rhodium(III)-catalyzed hydrazine-directed C-H activation: redox-neutral and traceless by N-N bond cleavage

Dongbing Zhao  1 , Zhuangzhi Shi, Frank Glorius
Affiliations

Indole synthesis by rhodium(III)-catalyzed hydrazine-directed C-H activation: redox-neutral and traceless by N-N bond cleavage

Dongbing Zhao et al. Angew Chem Int Ed Engl. .

Abstract

Fishing for complements! There is an alternative to the useful Fischer indole synthesis. The new method utilizes the same retrosynthetic disconnection but is based on a Rh(III) -catalyzed directed CH activation step and a successive coupling with alkynes.

Keywords: CH activation; heteroarenes; indoles; oxidizing directing groups; rhodium catalysis.

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