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Case Reports
. 2013 Nov 7;19(41):7213-6.
doi: 10.3748/wjg.v19.i41.7213.

Fecal microbiota transplantation for severe enterocolonic fistulizing Crohn's disease

Fa-Ming Zhang  1 , Hong-Gang Wang, Min Wang, Bo-Ta Cui, Zhi-Ning Fan, Guo-Zhong Ji
Affiliations
Case Reports

Fecal microbiota transplantation for severe enterocolonic fistulizing Crohn's disease

Fa-Ming Zhang et al. World J Gastroenterol. .

Abstract

The concept of fecal microbiota transplantation (FMT) has been used in traditional Chinese medicine at least since the 4(th) century. Evidence from recent human studies strongly supports the link between intestinal bacteria and inflammatory bowel disease. We proposed that standardized FMT might be a promising rescue therapy for refractory inflammatory bowel disease. However, there were no reports of FMT used in patients with severe Crohn's disease (CD). Here, we report the successful treatment of standardized FMT as a rescue therapy for a case of refractory CD complicated with fistula, residual Barium sulfate and formation of intraperitoneal large inflammatory mass. As far as we know, this is the first case of severe CD treated using FMT through mid-gut.

Trial registration: ClinicalTrials.gov NCT01793831.

Keywords: Crohn’s disease; Fecal microbiota transplantation; Fistula; Inflammatory bowel disease; Rescue therapy.

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Figures

Figure 1
Figure 1
Abdominal computerized tomography scan. A: Before FMT, formation of an intraperitoneal large inflammatory mass measuring 14 cm × 8 cm × 10 cm, arrows showing gas indicating fistula, and the scattered bright image indicating Barium sulfate in fistula; B: Four months after FMT, no mass and gas was present and only a little Barium sulfate in the mass was shown. FMT: Fecal microbiota transplantation.
See this image and copyright information in PMC

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