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Review
. 2013;15(3):113-7.

The case for hypofractionation of localized prostate cancer

Winnifred M Wong  1 , Kent E Wallner
Affiliations
Review

The case for hypofractionation of localized prostate cancer

Winnifred M Wong et al. Rev Urol. 2013.

Abstract

An optimal treatment regimen for localized prostate cancer (PCa) is yet to be determined. Increasing evidence reveals a lower α/β ratio for PCa with hypofractionated radiation therapy (HFRT) regimens introduced to exploit this change in therapeutic ratio. HFRT also results in shortened overall treatment times of 4 to 5 weeks, thus reducing staffing and machine burden, and, more importantly, patient stress. This review evaluates pretreatment characteristics, outcomes, and toxicity for 15 HFRT studies on localized PCa. HFRT results in comparable or better biochemical relapse-free survival and toxicity and is a viable option for localized PCa.

Keywords: Biologic equivalence; Dose escalation; Hypofractionation; Localized prostate cancer; Short-course radiotherapy.

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