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. 2013:2013:203873.
doi: 10.1155/2013/203873. Epub 2013 Oct 7.

Trail overexpression inversely correlates with histological differentiation in intestinal-type sinonasal adenocarcinoma

M Re  1 , A Santarelli, M Mascitti, F Bambini, L Lo Muzio, A Zizzi, C Rubini
Affiliations

Trail overexpression inversely correlates with histological differentiation in intestinal-type sinonasal adenocarcinoma

M Re et al. Int J Surg Oncol. 2013.

Abstract

Introduction: Despite their histological resemblance to colorectal adenocarcinoma, there is some information about the molecular events involved in the pathogenesis of intestinal-type sinonasal adenocarcinomas (ITACs). To evaluate the possible role of TNF-related apoptosis-inducing ligand (TRAIL) gene defects in ITAC, by investigating the immunohistochemical expression of TRAIL gene product in a group of ethmoidal ITACs associated with occupational exposure.

Material and methods: Retrospective study on 23 patients with pathological diagnosis of primary ethmoidal ITAC. Representative formalin-fixed, paraffin-embedded block from each case was selected for immunohistochemical studies using the antibody against TRAIL. Clinicopathological data were also correlated with the staining results.

Results: The immunohistochemical examination demonstrated that poorly differentiated cases showed a higher percentage of TRAIL expressing cells compared to well-differentiated cases. No correlation was found with other clinicopathological parameters, including T, stage and relapses.

Conclusion: The relationship between upregulation of TRAIL and poorly differentiated ethmoidal adenocarcinomas suggests that the mutation of this gene, in combination with additional genetic events, could play a role in the pathogenesis of ITAC.

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Figures

Figure 1
Figure 1
Poorly differentiated ethmoidal intestinal-type adenocarcinoma (G3) showing high percentage of TRAIL expressing cells (magnification 20x).
Figure 2
Figure 2
Poorly differentiated cases showed a higher percentage of TRAIL expressing cells in comparison to well-differentiated ethmoidal ITAC.
See this image and copyright information in PMC

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