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Meta-Analysis
. 2013 Nov 4;8(11):e79137.
doi: 10.1371/journal.pone.0079137. eCollection 2013.

C-Met as a prognostic marker in gastric cancer: a systematic review and meta-analysis

Shan Yu  1 , Yiyi Yu, Naiqing Zhao, Jianlan Cui, Wei Li, Tianshu Liu
Affiliations
Meta-Analysis

C-Met as a prognostic marker in gastric cancer: a systematic review and meta-analysis

Shan Yu et al. PLoS One. .

Abstract

Background: c-Met has been recognized as an important therapeutic target in gastric cancer, but the prognostic property of the c-Met status is still unclear. We aimed to characterize the prognostic effect of c-Met by systematic review and meta-analysis.

Methods: We identified 15 studies assessing survival in gastric cancer by c-Met status. Effect measure of interest was hazard ratio (HR) for survival. Meta-regression was performed to estimate the relationship between HR and disease stage. Random-effects meta-analyses were used to account for heterogeneity.

Results: 15 eligible studies provided outcome data stratified by c-Met status in 2210 patients. Meta-analysis of the HRs indicated a significantly poorer Os in patients with high c-Met expression (average HR=2.112, 95%CI: 1.622-2.748). Subgroup analysis showed the prognostic effect of c-Met was identical in protein-level and gene-level based methodology. The same effect was also seen in Asian and Western ethnicity subgroup analysis. Meta-regression showed HR was not associated with disease stage.

Conclusions: Patients with tumors that harbor high c-Met expression are more likely to have a worse Os, with this prognostic effect independent of disease stage. c-Met status should be evaluated in clinical prognosis.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. PRISMA flow Chart of selection process to identify eligible studies.
doi:10.1371/journal.pmed 1000097.
Figure 2
Figure 2. Forest plot showing the meta-analysis of hazard ratio estimates for OS in overall patients.
Figure 3
Figure 3. Forest plot showing the meta-analysis of hazard ratio estimates for OS in gene-level subgroup and protein-level subgroup.
Figure 4
Figure 4. Forest plot showing the meta-analysis of hazard ratio estimates for OS in Asian and Western subgroup.
Figure 5
Figure 5. Results of meta-regression.
ln(HR)-ln(percentage of advanced stage).
See this image and copyright information in PMC

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