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Clinical Trial
. 2014 Jan;14(1):210-5.
doi: 10.1111/ajt.12506. Epub 2013 Nov 13.

Secreted Wnt antagonists during eradication of cytomegalovirus infection in solid organ transplant recipients

T Ueland  1 , H Rollag, A Hartmann, A G Jardine, A Humar, A E Michelsen, A A Bignamini, A Åsberg, P Aukrust
Affiliations
Free article
Clinical Trial

Secreted Wnt antagonists during eradication of cytomegalovirus infection in solid organ transplant recipients

T Ueland et al. Am J Transplant. 2014 Jan.
Free article

Abstract

We evaluated secreted wingless (Wnt) modulators during cytomegalovirus (CMV) infection in solid organ transplant recipients (SOTr). The major findings were: (i) Plasma levels of Dickkopf-1 (DKK-1) were significantly lower in patients with CMV DNAemia above lower level of quantification at baseline. (ii) Receiver operating characteristic analysis indicated that low DKK-1 and increased secreted frizzled related protein-3 levels were predictors of poor virological outcomes during follow-up. Our findings demonstrate an imbalanced pattern of circulating secreted Wnt modulators in SOTr with poor virological outcomes following treatment for CMV disease, and may suggest a role for dysregulated Wnt signaling on viral pathogenesis during CMV infection.

Trial registration: ClinicalTrials.gov NCT00431353.

Keywords: CMV infection; Wnt signaling; solid organ transplant recipients; virological outcome.

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