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Comparative Study
. 1986 Feb;11(2):185-91.
doi: 10.1007/BF00967967.

Variations of brain histamine levels in germ-free and nephrectomized rats

L R Hegstrand, R J Hine
Comparative Study

Variations of brain histamine levels in germ-free and nephrectomized rats

L R Hegstrand et al. Neurochem Res. 1986 Feb.

Abstract

The influence of nephrectomy on brain and peripheral tissue histamine and on brain norepinephrine, dopamine, serotonin, and 5-hydroxyindoleacetic acid was studied in germ-free and conventionally housed rats. The conventional controls had higher levels of histamine in the hypothalamus than the germ-free control animals, but no differences existed for histamine in whole brain minus the hypothalamus or in peripheral tissues. Nephrectomy increased brain histamine and 5-hydroxyindoleacetic acid levels in both germ-free and conventional rats, but had no effect on norepinephrine, dopamine or serotonin. In contrast, the histamine level in the heart of the nephrectomized germ-free animals was lower than that for germ-free controls. There were no changes in the heart or liver histamine levels of the conventional nephrectomized rats.

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