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Comment
. 2013 Nov 26;110(48):19183-4.
doi: 10.1073/pnas.1319118110. Epub 2013 Nov 13.

HIV provides ample PAMPs for innate immune sensing

Benhur Lee  1
Affiliations
Comment

HIV provides ample PAMPs for innate immune sensing

Benhur Lee. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Innate immune sensing of DNA substrates. (A) HIV-derived ssDNA1 and mutant sequences that are poor (-), moderate (+) or good (+++) inducers of IFN-beta. (B) Structures of cGAS and IFI16 (HINb domain) bound to dsDNA (orange circle with spokes) indicate sequence-independent binding (14, 15). cGAMP, generated by cGAS upon DNA binding, activates STING directly (solid arrow). It is less clear how IFI16 (PY, Pyrin domain; HINa,b, DNA-binding domains) activates the STING-dependent ISD pathway (dashed arrow).
See this image and copyright information in PMC

Comment on

References

    1. Dixit E, Kagan JC. Intracellular pathogen detection by RIG-I-like receptors. Adv Immunol. 2013;117:99–125. - PMC - PubMed
    1. Stetson DB, Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity. 2006;24(1):93–103. - PubMed
    1. Ishikawa H, Barber GN. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature. 2008;455(7213):674–678. - PMC - PubMed
    1. Ishikawa H, Ma Z, Barber GN. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature. 2009;461(7265):788–792. - PMC - PubMed
    1. Unterholzner L. The interferon response to intracellular DNA: Why so many receptors? Immunobiology. 2013;218(11):1312–1321. - PubMed

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