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. 2014 Aug;16(8):679-83.
doi: 10.1177/1098612X13511812. Epub 2013 Nov 13.

Molecular characterisation and phylogenetic analysis of feline astrovirus in Korean cats

Yoon-Young Cho  1 , Seong-In Lim  2 , Young Kwan Kim  2 , Jae-Young Song  2 , Joong-Bok Lee  3 , Dong-Jun An  4
Affiliations

Molecular characterisation and phylogenetic analysis of feline astrovirus in Korean cats

Yoon-Young Cho et al. J Feline Med Surg. 2014 Aug.

Abstract

Astroviruses (AstVs) are important pathogens associated with enteric diseases in humans and other animals. However, most animal AstVs, including feline astrovirus (FAstV), are poorly understood. The aim of the present study was to investigate the prevalence and association of FAstV with enteric diseases in cats, and to conduct a molecular analysis of FAstVs, in Korea. Eleven faecal samples from 62 hospitalised cats at animal hospitals in the Moran market in South Korea tested positive for FAstV. The prevalence of FAstV was higher in cats <2 months old (25%) than in cats >2 months old (14.3%) (P = 0.31). Diarrhoea and normal faeces were observed in 19% (8/42) and 15% (3/20) of cats with FAstV, respectively (P = 1.00). Amino acid sequences alignment and phylogenetic tree analysis showed that FAstVs, including Korean strains, formed a single clade within the mamastroviruses.

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Conflict of interest statement

The authors do not have any potential conflicts of interest to declare.

Figures

Figure 1
Figure 1
Neighbour-joining (NJ) tree showing the phylogenetic relationships of feline astrovirus (FAstV) to other astrovirus (AstV) species based on partial ORF1b (a) and ORF2 (b) amino acids sequence analysis. The trees were constructed using the NJ method in Mega 4.1 software with 1000 bootstrap replicates. Bootstrap values >70% were observed on the branches. Korean FAstVs are highlighted in bold. The scale bar indicates the number of amino acid changes per site. HAstV = human AstV; PAstV/PoAstV = porcine AstV; ANV = avian nephritis virus
See this image and copyright information in PMC

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