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. 2013:2013:934239.
doi: 10.1155/2013/934239. Epub 2013 Oct 21.

Antioxidant, lipid lowering, and membrane stabilization effect of sesamol against doxorubicin-induced cardiomyopathy in experimental rats

Anusha Chennuru  1 , Mohamed T S Saleem
Affiliations

Antioxidant, lipid lowering, and membrane stabilization effect of sesamol against doxorubicin-induced cardiomyopathy in experimental rats

Anusha Chennuru et al. Biomed Res Int. 2013.

Abstract

The present study was designed to evaluate the cardioprotective effect of sesamol against doxorubicin-induced cardiomyopathy in rats. In this study, the cardioprotective effect of sesamol against doxorubicin induced cardiomyopathy in experimental rats was evaluated at the dosage of 50 mg/kg bw. Doxorubicin was administered to rats at a total cumulative dose of 15 mg/kg through intraperitoneal route for 2 weeks in six-divided dose on 8th, 10th, 14th, 16th, 18th, and 21st day. After the last dose administration, the endogenous antioxidants and lipid peroxidation were estimated in heart tissue homogenate. Cardiac biomarkers such as troponin T, LDH, CK, and AST and lipid profiles such as cholesterol, triglycerides, HDL, LDL, and VLDL were estimated in serum. Sesamol has cardioprotective activity through normalization of doxorubicin-induced-altered biochemical parameters. Biochemical study was further supported by histopathological study, which shows that sesamol offered myocardial protection from necrotic damage. From these findings, it has been concluded that the sesamol has significant cardioprotection against doxorubicin induced cardiomyopathy via amelioration of oxidative stress, lipid lowering, and membrane stabilization effect.

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Figures

Figure 1
Figure 1
Effect of sesamol on heart weight : body weight ratio. *P < 0.05 versus G1.
Figure 2
Figure 2
Light microscopical analysis of heart tissue: (G1) heart of rat received saline, (G2) heart of rat received sesamol, (G3) heart of rat received DOX, and (G4) heart of rat received sesamol+DOX.
See this image and copyright information in PMC

References

    1. Johnkennedy N, Ifeoma UH. Cardioprotective effect of Gnetum Bucholzianum leaf extract against doxorubicin cardiomyopathy in Wistar rats. Novel Science. 2012;1(3):61–64.
    1. Jin Z, Zhang J, Zhi H, et al. The beneficial effects of tadalafil on left ventricular dysfunction in doxorubicin-induced cardiomyopathy. Journal of Cardiology. 2013;62(2):110–116. - PubMed
    1. Ragavendran P, Sophia D, Arulraj A, Gopalakrishnan VK. Cardioprotective effect of aqueous, ethanol and aqueous ethanol extract of Aerva lanata (Linn.) against doxorubicin induced cardiomyopathy in rats. Asian Pacific Journal of Tropical Biomedicine. 2012;2(supplement 1):S212–S218.
    1. Octavia Y, Tocchetti CG, Gabrielson KL, Janssens S, Crijns HJ, Moens AL. Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. Journal of Molecular and Cellular Cardiology. 2012;52(6):1213–1225. - PubMed
    1. Prasad NR, Menon VP, Vasudev V, Pugalendi KV. Radioprotective effect of sesamol on γ-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes. Toxicology. 2005;209(3):225–235. - PubMed

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