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Comment
. 2013 Nov 11;24(5):562-3.
doi: 10.1016/j.ccr.2013.10.015.

Killing tumors by keeping ras and PI3' kinase apart

Tina L Yuan  1 , Frank McCormick
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Killing tumors by keeping ras and PI3' kinase apart

Tina L Yuan et al. Cancer Cell. .
Free article

Abstract

Ras proteins mediate PI3K activation through direct binding to p110 catalytic subunits. However, it is unclear when and where this interaction occurs. In this issue of Cancer Cell, Castellano and colleagues report that KRAS-driven lung cancers require the Ras-p110α interaction for full activation of PI3K and tumor maintenance.

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