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. 1986 Apr 8;25(7):1545-8.
doi: 10.1021/bi00355a013.

Neonatal human foreskin keratinocytes produce 1,25-dihydroxyvitamin D3

D D Bikle, M K Nemanic, J O Whitney, P W Elias

Neonatal human foreskin keratinocytes produce 1,25-dihydroxyvitamin D3

D D Bikle et al. Biochemistry. .

Abstract

Primary cultures of neonatal human foreskin keratinocytes converted 25-hydroxyvitamin D in high yield to a metabolite with the chromatographic behavior of 1,25-dihydroxyvitamin D3. The identity of this metabolite as 1,25-dihydroxyvitamin D3 was confirmed both by its potency in displacing 1,25-dihydroxyvitamin D3 in the chick cytosol receptor assay and by mass spectral analysis. These results suggest that 1,25-dihydroxyvitamin D3 may be formed in the epidermis to regulate vitamin D production by the epidermis and to provide an alternative to 1,25-dihydroxyvitamin D3 production by the kidneys.

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