[Inhibition by alpha-D-galactose of heterophilic antibodies against the antigens of the interstitial connective tissue of the myocardium]

Abstract

The reaction of heterophile antibodies with interstitial connective tissue cells of bovine myocardium was inhibited with alpha-D-galactose. D-glucose, D-mannose, L-fucose, N-acetylgalactosamine and other monosaccharides demonstrated the lack of inhibitory activity. Disaccharide melibiose and trisaccharide raffinose containing terminal alpha-galactose also had an inhibitory effect on the reaction of sera with bovine myocardium. The results show that heterophile antibodies to heterophile bovine antigen revealed in rheumatic patients' sera differ from antibodies to I and i antigens and T-antibodies, whose specificity is associated with terminal beta-galactose. They also differ from other heterophile antibodies described earlier.