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Review
. 2014;10(2):360-7.
doi: 10.4161/hv.27087. Epub 2013 Nov 14.

Coxsackievirus A16: epidemiology, diagnosis, and vaccine

Qunying Mao  1 , Yiping Wang  1 , Xin Yao  1 , Lianlian Bian  1 , Xing Wu  1 , Miao Xu  1 , Zhenglun Liang  1
Affiliations
Review

Coxsackievirus A16: epidemiology, diagnosis, and vaccine

Qunying Mao et al. Hum Vaccin Immunother. 2014.

Abstract

Coxsackievirus 16 (CA16) is one of the major pathogens associated with hand, foot, and mouth disease (HFMD) in infants and young children. In recent years, CA16 and human enterovirus 71 (EV71) have often circulated alternatively or together in the Western Pacific region, which has become an important public health problem in this region. HFMD caused by CA16 infection is generally thought to be mild and self-limiting. However, recently several severe and fatal cases involving CA16 have been reported. Studies have shown that co-infection with CA16 and EV71 can cause serious complications in the central nervous system (CNS) and increase the chance of genetic recombination, which may be responsible for the large HFMD outbreak in Mainland China in 2008. For these reasons, recent studies have focused on the virological characteristics of CA16 and the development of CA16-related diagnostic reagents and vaccines.

Keywords: Coxsackievirus A16 (CA16); animal model; neutralizing antibody; recombination; vaccine.

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References

    1. Sickles GM, Mutterer M, Feorino P, Plager H. Recently classified types of Coxsackie virus, group A; behavior in tissue culture. Proc Soc Exp Biol Med. 1955;90:529–31. doi: 10.3181/00379727-90-22088. - DOI - PubMed
    1. Ranganathan S, Singh S, Poh CL, Chow VT. The hand, foot and mouth disease virus capsid: sequence analysis and prediction of antigenic sites from homology modelling. Appl Bioinformatics. 2002;1:43–52. - PubMed
    1. Zou XN, Zhang XZ, Wang B, Qiu YT. Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases. Braz J Infect Dis. 2012;16:457–65. doi: 10.1016/j.bjid.2012.08.001. - DOI - PubMed
    1. Shi J, Huang X, Liu Q, Huang Z. Identification of conserved neutralizing linear epitopes within the VP1 protein of coxsackievirus A16. Vaccine. 2013;31:2130–6. doi: 10.1016/j.vaccine.2013.02.051. - DOI - PubMed
    1. Goto K, Sanefuji M, Kusuhara K, Nishimura Y, Shimizu H, Kira R, Torisu H, Hara T. Rhombencephalitis and coxsackievirus A16. Emerg Infect Dis. 2009;15:1689–91. doi: 10.3201/eid1510.090594. - DOI - PMC - PubMed

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