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Editorial
. 2014;13(1):3-4.
doi: 10.4161/cc.27018. Epub 2013 Nov 14.

RNA secondary structure-dependent termination of transcription

Nikolay Zenkin  1
Affiliations
Editorial

RNA secondary structure-dependent termination of transcription

Nikolay Zenkin. Cell Cycle. 2014.
No abstract available

Keywords: RNA hairpin; RNA polymerase; RNA secondary structure; elongation complex; last universal common ancestor; molecular evolution; pausing; termination; transcription.

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Figure 1. RNA secondary structure (RSS)-dependent termination of transcription. Multi-subunit RNAP and nucleic acids of the elongation complex are shown as a transparent surface and in space fill, respectively. Folding of RSS 7 base pairs upstream of the RNAP active center is incompatible with conformation of the stable elongation complex. RSS may be provided by a dedicated hairpin at the end of the gene or by the fully folded functional transcript (in this example tRNA), in which case it is formed by the most 3′ and 5′ proximal parts of the transcript.
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References

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