Interleukin-4 and acetaminophen hepatotoxicity: a story of conflicting results and conclusions
- PMID: 24232263
- PMCID: PMC3943743
- DOI: 10.1007/s00011-013-0686-0
Interleukin-4 and acetaminophen hepatotoxicity: a story of conflicting results and conclusions
Comment on
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Interleukin-4 deficiency protects mice from acetaminophen-induced liver injury and inflammation by prevention of glutathione depletion.Inflamm Res. 2014 Jan;63(1):61-9. doi: 10.1007/s00011-013-0671-7. Epub 2013 Oct 8. Inflamm Res. 2014. PMID: 24100592
References
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- Pires DA, Marques PE, Pereira RV, David BA, Gomides LF, Dias AC, Nunes-Silva A, Pinho V, Cara DC, Vieira LQ, Teixeira MM, Menezes GB. Interleukin-4 deficiency protects mice from acetaminophen-induced liver injury and inflammation by prevention of glutathione depletion. Inflamm Res. 2013 Oct 8; Epub ahead of print. - PubMed
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- Knight TR, Ho YS, Farhood A, Jaeschke H. Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione. J Pharmacol Exp Ther. 2002;303:468–75. - PubMed
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- McGill MR, Lebofsky M, Norris HR, Slawson MH, Bajt ML, Xie Y, Williams CD, Wilkins DG, Rollins DE, Jaeschke H. Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. Toxicol Appl Pharmacol. 2013;269:240–9. - PMC - PubMed
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