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Case Reports
. 2013 Oct 8:4:137.
doi: 10.4103/2152-7806.119537. eCollection 2013.

Primary human chorionic gonadotropin secreting germinoma of the corpus callosum

Foo Song Chuan Aaron  1 , Chong Q Q Dawn, Chang T E Kenneth, Ng Wai Hoe, Soh Shui Yen, Tham Chee Kian
Affiliations
Case Reports

Primary human chorionic gonadotropin secreting germinoma of the corpus callosum

Foo Song Chuan Aaron et al. Surg Neurol Int. .

Abstract

Background: Primary intracranial germinomas are a rare subset of intracranial tumors derived from mis-incorporated germ cells within the folding neural plate during embryogenesis. Though known to arise from midline structures in the central nervous system (CNS), occurrence within the corpus callosum is exceedingly rare.

Case description: We present a rare case of secreting primary intracranial germinoma with extensive intraventricular metastasis presenting as a multi-cystic butterfly lesion in the genu of the corpus callosum in a young boy.

Conclusion: Intracranial germ cell tumors must be considered for any multi-cystic lesion arising from midline structures in the CNS in the preadult population.

Keywords: Corpus callosum; germinoma; intracranial; secreting.

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Figures

Figure 1
Figure 1
Contrasted CT of tumor in corpus callosum with intraventricular involvement
Figure 2
Figure 2
Noncontrasted MRI of tumor in corpus callosum with intraventricular involvement
Figure 3
Figure 3
Photomicrograph of germinoma (H and E, ×200) featuring sheets of large primitive cells with round nuclei bearing prominent nucleoli, and ample clear cytoplasm with discrete cell membranes, interrupted by fibrous septa containing smaller reactive lymphocytes
Figure 4
Figure 4
Contrasted MRI 1 month after completion of treatment
See this image and copyright information in PMC

References

    1. Aoyama H, Shirato H, Ikeda J, Fujieda K, Miyasaka K, Sawamura Y. Induction chemotherapy followed by low-dose involved-field radiotherapy for intracranial germ cell tumors. J Clin Oncol. 2002;20:857–65. - PubMed
    1. Bourekas EC, Varakis K, Bruns D, Christoforidis GA, Baujan M, Slone HW, et al. Lesions of the corpus callosum: MR imaging and differential considerations in adults and children. AJR Am J Roentgenol. 2002;179:251–7. - PubMed
    1. Calaminus G, Kortmann R, Worch J, Nicholson JC, Alapetite C, Garrè ML, et al. SIOP CNS GCT 96: Final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease. Neuro Oncol. 2013;15:788–96. - PMC - PubMed
    1. Carrillo R, Ricoy JR, Del Pozo JM, García-Uria J, Herrero J. Dissemination with malignant changes from a pineal tumor through the corpus callosum after total removal. Childs Brain. 1977;3:230–7. - PubMed
    1. Chen YW, Huang PI, Hu YW, Ho DM, Chang KP, Guo WY, et al. Treatment strategies for initially disseminated intracranial germinomas: Experiences at a single institute. Childs Nerv Syst. 2012;28:557–63. - PubMed

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