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. 1986 Feb;5(2):409-13.
doi: 10.1002/j.1460-2075.1986.tb04226.x.

Location of 'continuous' antigenic determinants in the protruding regions of proteins

J M Thornton, M S Edwards, W R Taylor, D J Barlow

Location of 'continuous' antigenic determinants in the protruding regions of proteins

J M Thornton et al. EMBO J. 1986 Feb.

Abstract

A simple method is described to locate 'antigenic' peptides from the alpha-carbon co-ordinates of a protein, based on protrusion from the protein's globular surface. A good correlation is found between those parts of a protein which protrude and the experimentally determined antigenic peptides in myoglobin, lysozyme and myohemerythrin. A comparison is made between the use of protrusion index, mobility, solvent accessibility and hydrophilicity for predicting the most likely antigenic peptides.

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