Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-Ia antisera
- PMID: 2423435
- PMCID: PMC1452627
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Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-Ia antisera
Immunology.
1986 May.
Abstract
Columnar epithelial cells (EC), isolated from the proximal small intestine of the rat, bind ovalbumin (OVA) by a non-specific, cold-inhibitable mechanism and continue to express Ia antigens after 24 hr culture in vitro. Lymph node T cells from rats immunized with OVA proliferate following 18 hr coculture with EC and OVA. This accessory cell function of EC is antigen-specific and is blocked by anti-Ia monoclonal antisera.
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