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Comment
. 2013 Nov 15;188(10):1264-5.
doi: 10.1164/rccm.201305-0810LE.

Moving forward in sepsis research

S Ananth Karumanchi  1 , Samir M Parikh
Affiliations
Comment

Moving forward in sepsis research

S Ananth Karumanchi et al. Am J Respir Crit Care Med. .
No abstract available

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Comment in

  • Reply: Moving forward in sepsis research.
    Perlman H, Budinger GR, Ward PA. Perlman H, et al. Am J Respir Crit Care Med. 2013 Nov 15;188(10):1265-6. doi: 10.1164/rccm.201305-0997LE. Am J Respir Crit Care Med. 2013. PMID: 24236593 No abstract available.

Comment on

  • Genomic responses in mouse models poorly mimic human inflammatory diseases.
    Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, López CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, Cobb JP, Rahme LG, Lowry SF, Maier RV, Moldawer LL, Herndon DN, Davis RW, Xiao W, Tompkins RG; Inflammation and Host Response to Injury, Large Scale Collaborative Research Program. Seok J, et al. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12. doi: 10.1073/pnas.1222878110. Epub 2013 Feb 11. Proc Natl Acad Sci U S A. 2013. PMID: 23401516 Free PMC article. Clinical Trial.
  • Humanizing the mouse: in defense of murine models of critical illness.
    Perlman H, Budinger GR, Ward PA. Perlman H, et al. Am J Respir Crit Care Med. 2013 May 1;187(9):898-900. doi: 10.1164/rccm.201303-0489ED. Am J Respir Crit Care Med. 2013. PMID: 23634853 Free PMC article. No abstract available.

References

    1. Perlman H, Budinger GRS, Ward PA. Humanizing the mouse: in defense of murine models of critical illness [editorial] Am J Respir Crit Care Med. 2013;187:898–900. - PMC - PubMed
    1. Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, et al. Inflammation and Host Response to Injury, Large Scale Collaborative Research Program. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci USA. 2013;110:3507–3512. - PMC - PubMed
    1. Opal SM, Laterre PF, Francois B, LaRosa SP, Angus DC, Mira JP, Wittebole X, Dugernier T, Perrotin D, Tidswell M, et al. ACCESS Study Group. Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA. 2013;309:1154–1162. - PubMed
    1. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998;282:2085–2088. - PubMed
    1. David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM. Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis. Crit Care Med. 2012;40:3034–3041. - PMC - PubMed

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