Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 May;31(5):559-63.
doi: 10.1111/dme.12360. Epub 2013 Dec 6.

Increased intestinal permeability to oral chromium (51 Cr) -EDTA in human Type 2 diabetes

F Horton  1 , J Wright, L Smith, P J Hinton, M D Robertson
Affiliations

Increased intestinal permeability to oral chromium (51 Cr) -EDTA in human Type 2 diabetes

F Horton et al. Diabet Med. 2014 May.

Abstract

Objective: In animal models of obesity and Type 2 diabetes, permeability of the intestine is increased because of impairment of tight junction proteins, allowing translocation of bacterial endotoxin and resulting in low-grade systemic inflammation. This has yet to be demonstrated in humans. The objective of this study was the demonstration of increased intestinal permeability in human Type 2 diabetes.

Methods: We examined intestinal permeability using chromium ((51) Cr)-EDTA urinary recovery in twenty well-controlled men with Type 2 diabetes compared with control subjects matched for age, gender and BMI.

Results: Intestinal permeability was significantly increased (P = 0.002) in the diabetic group and was correlated to increased levels of systemic inflammatory markers high-sensitivity C-reactive protein (r = 0.694, P = 0.001), interleukin 6 (r = 0.548, P = 0.012) and tumour necrosis factor alpha (r = 0.564, P = 0.010).

Conclusion: This is the first demonstration that increased intestinal permeability may be a feature of human Type 2 diabetes.

PubMed Disclaimer

Publication types

MeSH terms