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Comment
. 2013 Nov 13;14(5):488-90.
doi: 10.1016/j.chom.2013.10.015.

TLR5 stops commensals in their tracks

Meghan A Koch  1 , Gregory M Barton
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Free article
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TLR5 stops commensals in their tracks

Meghan A Koch et al. Cell Host Microbe. .
Free article

Abstract

IgA antibodies help maintain intestinal immune homeostasis with resident commensal species; however, the precise mechanisms regulating IgA induction and the epitopes recognized by these antibodies remain incompletely understood. In this issue of Cell Host & Microbe, Tyler et al. (2013) demonstrate that TLR5-dependent induction of anti-flagellin antibodies prevents commensal association with the intestinal mucosa by limiting bacterial motility.

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