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Review
. 2013 Dec;60(6):1383-91.
doi: 10.1016/j.pcl.2013.08.008. Epub 2013 Oct 4.

Thalassemias

Alissa Martin  1 , Alexis A Thompson
Affiliations
Review

Thalassemias

Alissa Martin et al. Pediatr Clin North Am. 2013 Dec.

Abstract

The thalassemia syndromes are hemoglobin disorders that result from significantly reduced or absent synthesis of either the α- or β-globin chains. The result is a chronic hemolytic anemia with ineffective erythropoiesis and bone marrow overstimulation. This article reviews current diagnostic approaches, complications, and disease management of thalassemia.

Keywords: Anemia; Hemoglobinopathies; Iron overload; Thalassemia.

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