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Randomized Controlled Trial
. 2014 May;29(5):889-94.
doi: 10.1016/j.arth.2013.10.005. Epub 2013 Oct 16.

Topical administration of tranexamic acid in primary total hip and total knee arthroplasty

Affiliations
Randomized Controlled Trial

Topical administration of tranexamic acid in primary total hip and total knee arthroplasty

Joseph G Martin et al. J Arthroplasty. 2014 May.

Abstract

Major blood loss is a known potential complication in total hip and total knee arthroplasty. We conducted a prospective, stratified, randomized, double-blind, placebo-controlled trial that evaluated 100 patients undergoing total knee or total hip arthroplasty to evaluate the effect on blood loss using the topical application of tranexamic acid. Participants received either 2 g of topical tranexamic acid or the equivalent volume of placebo into the joint prior to surgical closure. Tranexamic acid resulted in a lower mean maximum decline in postoperative hemoglobin levels when compared to placebo (P = 0.013). Patients in the tranexamic acid group demonstrated an improved but non-significant reduction in the units of blood transfused compared to placebo (P = 0.423). There was no clinically significant increase in complications in the tranexamic acid group, including no incidence of venous thromboembolism.

Keywords: blood loss; blood transfusion; hemoglobin; total hip arthroplasty; total knee arthroplasty; tranexamic acid.

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