Topical administration of tranexamic acid in primary total hip and total knee arthroplasty
- PMID: 24238825
- DOI: 10.1016/j.arth.2013.10.005
Topical administration of tranexamic acid in primary total hip and total knee arthroplasty
Abstract
Major blood loss is a known potential complication in total hip and total knee arthroplasty. We conducted a prospective, stratified, randomized, double-blind, placebo-controlled trial that evaluated 100 patients undergoing total knee or total hip arthroplasty to evaluate the effect on blood loss using the topical application of tranexamic acid. Participants received either 2 g of topical tranexamic acid or the equivalent volume of placebo into the joint prior to surgical closure. Tranexamic acid resulted in a lower mean maximum decline in postoperative hemoglobin levels when compared to placebo (P = 0.013). Patients in the tranexamic acid group demonstrated an improved but non-significant reduction in the units of blood transfused compared to placebo (P = 0.423). There was no clinically significant increase in complications in the tranexamic acid group, including no incidence of venous thromboembolism.
Keywords: blood loss; blood transfusion; hemoglobin; total hip arthroplasty; total knee arthroplasty; tranexamic acid.
© 2014.
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