Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Mar;35(3):97-104.
doi: 10.1016/j.it.2013.10.006. Epub 2013 Nov 13.

SeXX matters in immunity

J G Markle  1 , E N Fish  2
Affiliations
Review

SeXX matters in immunity

J G Markle et al. Trends Immunol. 2014 Mar.

Abstract

The significant contributions of sex to an immune response, specifically in the context of the sex bias observed in susceptibility to infectious and autoimmune diseases and their pathogenesis, have until recently, largely been ignored and understudied. This review highlights recent findings related to sex-specific factors that provide new insights into how sex determines the transcriptome, the microbiome, and the consequent immune cell functional profile to define an immune response. Unquestionably, accumulating data confirm that sex matters and must be a consideration when decisions around therapeutic intervention strategies are developed.

Keywords: autoimmunity; immune response; infection; sex; vaccination.

PubMed Disclaimer

Publication types