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. 2014 Jan 3;588(1):41-6.
doi: 10.1016/j.febslet.2013.10.046. Epub 2013 Nov 12.

Heterogeneity of koala retrovirus isolates

Sayumi Shimode  1 , So Nakagawa  2 , Rokusuke Yoshikawa  1 , Takayuki Shojima  1 , Takayuki Miyazawa  3
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Free article

Heterogeneity of koala retrovirus isolates

Sayumi Shimode et al. FEBS Lett. .
Free article

Abstract

Koala retrovirus (KoRV) is a gammaretrovirus which may induce immune suppression, leukemia and lymphoma in koalas. Currently three KoRV subgroups (A, B, and J) have been reported. Our phylogenetic analysis suggests that KoRV-B and KoRV-J should be classified as the same subgroup. In long terminal repeat (LTR), a KoRV-B isolate has four 17 bp tandem repeats named direct repeat (DR)-1, while a KoRV-J isolate (strain OJ-4) has three 37 bp tandem repeats named DR-2. We also found that the promoter activity of the KoRV-J strain OJ-4 is stronger than that of original KoRV-A, suggesting that KoRV-J may replicate more efficiently than KoRV-A.

Keywords: Gammaretrovirus; Koala; Leukemia; Promoter activity; Subgroup.

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