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Comment
. 2014 Jan 15;20(2):278-80.
doi: 10.1158/1078-0432.CCR-13-2626. Epub 2013 Nov 15.

Pertuzumab protects the achilles' heel of trastuzumab--emtansine

William R Gwin  1 , Neil L Spector
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Comment

Pertuzumab protects the achilles' heel of trastuzumab--emtansine

William R Gwin et al. Clin Cancer Res. .

Abstract

Trastuzumab emtansine (T-DM1) represents a significant advancement in the treatment of HER2(+) breast cancers. Its clinical efficacy however will be limited by the development of therapeutic resistance. In this report, the HER3 ligand neuregulin is shown to mediate T-DM1 resistance, which was overcome by administration of pertuzumab, a steric inhibitor of HER2 dimerization.

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