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Comment
. 2013 Oct 24;155(3):495-7.
doi: 10.1016/j.cell.2013.10.012. Epub 2013 Oct 24.

First steps toward a globally effective HIV/AIDS vaccine

David Palesch  1 , Frank Kirchhoff
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Free article
Comment

First steps toward a globally effective HIV/AIDS vaccine

David Palesch et al. Cell. .
Free article

Abstract

The enormous diversity of HIV-1 presents a formidable challenge for developing an effective AIDS vaccine. In this issue of Cell, Barouch et al. show that bioinformatically designed antigens, pieced together from multiple HIV immune epitopes, partially protect rhesus macaques from simian-human immunodeficiency virus infection. This "mosaic" approach holds promise for the development of broadly protective vaccines.

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  • Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys.
    Barouch DH, Stephenson KE, Borducchi EN, Smith K, Stanley K, McNally AG, Liu J, Abbink P, Maxfield LF, Seaman MS, Dugast AS, Alter G, Ferguson M, Li W, Earl PL, Moss B, Giorgi EE, Szinger JJ, Eller LA, Billings EA, Rao M, Tovanabutra S, Sanders-Buell E, Weijtens M, Pau MG, Schuitemaker H, Robb ML, Kim JH, Korber BT, Michael NL. Barouch DH, et al. Cell. 2013 Oct 24;155(3):531-9. doi: 10.1016/j.cell.2013.09.061. Epub 2013 Oct 24. Cell. 2013. PMID: 24243013 Free PMC article.

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