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. 1986 May 29;137(1):149-53.
doi: 10.1016/0006-291x(86)91188-5.

Effect of sustained exercise on concentrations of plasma aromatic and branched-chain amino acids and brain amines

I Acworth, J Nicholass, B Morgan, E A Newsholme

Effect of sustained exercise on concentrations of plasma aromatic and branched-chain amino acids and brain amines

I Acworth et al. Biochem Biophys Res Commun. .

Abstract

In both trained and untrained rats, exercise increased the plasma concentration ratio of aromatic amino acids to branched-chain amino acids which might favour entry of the aromatic amino acids into the brain. Exercise in trained rats did not change the brain concentration of 5-hydroxytryptamine but increased that of 5-hydroxyindole acetic acid. Exercise in the untrained rat increased the concentration of brain tryptophan and that of 5-hydroxytryptamine but that of 5-hydroxyindole acetic acid was unchanged. The increased concentration of 5-hydroxytryptamine in untrained rats might be involved in central fatigue.

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