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. 2013 Oct 1;2(10):e25990.
doi: 10.4161/onci.25990. Epub 2013 Sep 12.

Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis

Christian Hirt  1 , Serenella Eppenberger-Castori, Giuseppe Sconocchia, Giandomenica Iezzi, Luigi Tornillo, Luigi Terracciano, Giulio C Spagnoli, Raoul A Droeser
Affiliations

Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis

Christian Hirt et al. Oncoimmunology. .

Abstract

The prognostic relevance of innate immune cells infiltrating colorectal carcinoma lesions is highly debated. By evaluating the expression of myeloperoxidase (MPO) as a marker of neutrophil granulocytes in a large cohort of colorectal carcinoma specimens, we have observed that robust tumor-infiltration by MPO+ cells correlates with improved patient survival independently of other histopathological parameters, including disease stage.

Keywords: CD15; human colorectal cancer; mismatch repair status; myeloperoxidase; prognosis; tissue microarray.

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Figures

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Figure 1. Molecular mechanisms potentially underlying the favorable effects of myeloperoxidase-expressing neutrophil granulocytes in colorectal carcinoma. Myeloperoxidase (MPO)-expressing neutrophil granulocytes (NGs) might exert direct antitumor effects on opsonized cancer cells (1), or they might be recruited to neoplastic lesions by the secretion of immunostimulatory cytokines including interleukin-8 (IL-8) and granulocyte macrophage colony-stimulating factor (GM-CSF) (2). The activation of MPO+ NGs by danger-associated molecular patterns (DAMPs) released by dying tumor cells or by microbiota-derived pathogen-associated molecular patterns (PAMPs) might further promote the antitumor activity of these cells (3).
See this image and copyright information in PMC

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