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Comment
. 2014 Feb;92(2):99-100.
doi: 10.1038/icb.2013.83. Epub 2013 Nov 19.

A γδ T-cell glimpse of glycolipids

Dirk M Zajonc  1 , Enrico Girardi  1
Affiliations
Comment

A γδ T-cell glimpse of glycolipids

Dirk M Zajonc et al. Immunol Cell Biol. 2014 Feb.
No abstract available

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Figures

Figure 1
Figure 1
Antigen recognition spectrum of T cells. (a) αβ T cells have been shown to recognize a range of diverse antigens, such as peptides, lipids and small metabolites, but only when bound to an antigen-presenting molecule. This population includes classical peptide-reactive T cells, lipid-reactive NKT cells and metabolite-reactive Mucosal associated invariant T (MAIT) cells. γδ T cells, in contrast, can recognize antigen-presenting molecules in the absence or presence of antigen. (b) Schematic representation of the modes of binding of αβ and γδ TCRs to CD1d molecules. CD1d is shown in gray with the two main pockets, A′ and F′, composing the binding groove. The two chains forming the TCR are shown as ellipsoids together with a line connecting the center of masses of each V domain. Note how the Vδ1 γδ TCR (top) binds on the opposite side of CD1d compared with the type I NKT TCR (middle), but similar to the binding of a mouse type II NKT TCR to mouse CD1d (bottom).
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Comment on

  • CD1d-lipid antigen recognition by the γδ TCR.
    Uldrich AP, Le Nours J, Pellicci DG, Gherardin NA, McPherson KG, Lim RT, Patel O, Beddoe T, Gras S, Rossjohn J, Godfrey DI. Uldrich AP, et al. Nat Immunol. 2013 Nov;14(11):1137-45. doi: 10.1038/ni.2713. Epub 2013 Sep 29. Nat Immunol. 2013. PMID: 24076636

References

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