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Case Reports
. 2013 Fall;25(4):343-5.
doi: 10.1176/appi.neuropsych.12110286.

Agomelatine treatment of major depressive disorder in Parkinson's disease: a case series

Domenico De Berardis, Michele Fornaro, Nicola Serroni, Luigi Olivieri, Stefano Marini, Francesco Saverio Moschetta, Venkataramanujam Srinivasan, Maurizio Assetta, Alessandro Valchera, Anatolia Salone, Giovanni Martinotti, Marco Onofrj, Massimo Di Giannantonio
Case Reports

Agomelatine treatment of major depressive disorder in Parkinson's disease: a case series

Domenico De Berardis et al. J Neuropsychiatry Clin Neurosci. 2013 Fall.

Abstract

Major Depressive Disorder (MDD) is among the most frequent comorbidities occurring in the course of Parkinson's disease (PD), and therefore, most PD patients receive antidepressant drugs. Agomelatine is a recently introduced antidepressant drug acting as an MT1/MT2 melatonergic receptor agonist and 5HT2C/5HT2B serotonergic antagonist. The aim of this case series was to evaluate the role of agomelatine in the treatment of MDD associated with PD.

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