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Case Reports
. 2013 May;17(2):261-5.
doi: 10.4103/0973-029X.119749.

Centroblastic variant of diffuse large B-cell lymphoma: Case report and review of literature

Preethi B Nayak  1 , Dinkar Desai, Siddharth Pandit, Nisha Rai
Affiliations
Case Reports

Centroblastic variant of diffuse large B-cell lymphoma: Case report and review of literature

Preethi B Nayak et al. J Oral Maxillofac Pathol. 2013 May.

Abstract

Diffuse large B-cell lymphoma (DLBCL) is a subtype of non-Hodgkin's lymphoma (NHL) making up about approximately 30% of all NHL. Its occurrence in the mandible is very rare. Histopathologically, five variants of DLBCL have been recognized among which centroblastic variant is the one with better prognosis. We report a case of a 55 year-old patient who presented with a painless swelling in the lower right body of the mandible since 4 months. Incisional biopsy revealed NHL like features, confirmed by immunohistochemistry using CD45, CD20, and CD3 markers to be a DLBCL of centroblastic variant. Patient was treated with chemotherapy following which the lesion regressed completely with no further recurrences. Precise histological diagnosis is crucial for the clinical management and ultimately for the survival of the patient.

Keywords: Centroblastic variant; diffuse large B-cell lymphoma; extranodal; immunohistochemistry; non-Hodgkin's lymphoma.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Computed Tomography of mandible showing an osteolytic lesion with soft tissue density in the body of the mandible
Figure 2
Figure 2
Photomicrograph shows diffuse large lymphoblasts arranged in sheets (H&E stain, ×400)
Figure 3
Figure 3
Immunohistochemistry shows positivity for CD45 (IHC stain, ×400)
Figure 4
Figure 4
Immunohistochemistry shows positivity for CD20 (IHC stain, ×400)
Figure 5
Figure 5
Photomicrograph showing centroblasts with vesicular nuclei, prominent nucleoli and basophilic cytoplasm (H&E stain, ×400)
See this image and copyright information in PMC

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