Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 May;17(2):320.
doi: 10.4103/0973-029X.119773.

Primary extra-nodal non-Hodgkin's lymphoma of gingiva: A diagnostic dilemma

Sameer Parihar  1 , Rajeev K Garg, Pooja Narain
Affiliations
Case Reports

Primary extra-nodal non-Hodgkin's lymphoma of gingiva: A diagnostic dilemma

Sameer Parihar et al. J Oral Maxillofac Pathol. 2013 May.

Abstract

Primary non-Hodgkin's lymphoma (NHL) is a rare entity. When it does occur, mandibular NHL typically manifests similar to an odontogenic pathology. This results in delayed diagnosis and treatment. We present a 50-year-old female who was erroneously treated for a pyogenic granuloma several months before the correct diagnosis of extranodal primary NHL of the oral cavity was made. Fortunately, the solitary bony lymphoma had not disseminated and management by chemo-radiation allowed for disease eradication and new post-treatment bone formation. The purpose of this report is to describe a rare case of primary NHL of the mandible, explore the diagnosis and work-up and discuss treatment strategies. This case illustrates the need for co-operative diagnostic referrals between physicians and dentists.

Keywords: Cyclophosphamide hydroxydaunorubicin oncovin prednisolone-rituximab therapy; extranodal; mandibular swelling; non-Hodgkin's lymphoma.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Intra-oral clinical view of the lesion depicting mandibular labial sulcus involvement and displacement of the adjoining teeth
Figure 2
Figure 2
Histologic view of the lesion. Cells have round or oval nucleus with multilobed or cleaved nuclei. Large lymphocytes are more in number than small lymphocytes (H&E stain, ×400)
Figure 3
Figure 3
Immunohistochemistry showing pleomorphic cells diffusely positive for CD20 marker (×200)
See this image and copyright information in PMC

References

    1. Salhany KE, Pietra GG. Extranodal lymphoid disorders. Am J Clin Pathol. 1993;99:472–85. - PubMed
    1. Burke JS. Waldeyer's ring, sinonasal region, salivary gland, thyroid gland, Central nervous system, and other extranodal lymphomas and lymphoid hyperplasias. In: Knowles DM, editor. Neoplastic Hematopathology. 2nd ed. Philadelphia: Lippincott Williams and Willkins; 2001. pp. 1351–90.
    1. Ferry JA, Harris NL. Lymphomas and lymphoid hyperplasia in head and neck sites. In: Pilch BZ, editor. Head and Neck Surgical Pathology. 1st ed. Philadelphia: Lippincott Williams and Wilkins; 2001. pp. 476–533.
    1. Richards A, Costelloe MA, Eveson JW, Scully C, Irvine GH, Rooney N. Oral mucosal non-Hodgkin's lymphoma: A dangerous mimic. Oral Oncol. 2000;36:556–8. - PubMed
    1. Castellano S, Carbone M, Carrozzo M, Broccoletti R, Pagano M, Vasino MA, et al. Onset of oral extranodal large B-cell non-Hodgkin's lymphoma in a patient with polycythemia vera: A rare presentation. Oral Oncol. 2002;38:624–6. - PubMed

Publication types