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Case Reports
. 2013 Oct 15:7:263-8.
doi: 10.4137/CMO.S12403. eCollection 2013.

Leiomyosarcoma of the splenic vein

Cristian Aguilar  1 , Francisco Socola, Jean A Donet, Nicolas Gallastegui, Gabriel A Hernandez
Affiliations
Case Reports

Leiomyosarcoma of the splenic vein

Cristian Aguilar et al. Clin Med Insights Oncol. .

Abstract

Leiomyosarcomas arising from the wall of blood vessels are rare and aggressive neoplasm. We report a case of a previously healthy 66-year-old woman who presented with intermittent abdominal pain, progressive constipation, and weight loss. Abdominal computed tomography showed a 12 cm solid heterogeneous tumor in the tail of the pancreas. The patient subsequently underwent surgical resection of the pancreatic mass. Surprisingly, histological and immunohistochemical analyses revealed leiomyosarcoma arising from the smooth muscle of the splenic vein. After surgery, she received adjuvant chemotherapy. One year later, there was no evidence of local recurrence. In this paper, we discuss the available information about leiomyosarcomas of splenic vein and its management.

Keywords: leiomyosarcoma; sarcomas of the great vessels; splenic vein.

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Figures

Figure 1
Figure 1
Abdominal computed tomography showed a solid heterogeneous tumor of 12 cm in diameter in the tail of the pancreas with central necrosis (blue arrow indicates the tumor).
Figure 2
Figure 2
Cut section of the 12 × 9 × 6 cm grayish-brown color tumor. It was solid and firm with focal areas of hemorrhage arising from the smooth muscle of the splenic vein.
Figure 3
Figure 3
Hematoxylin and eosin stain (4× magnifications) revealed predominantly fusiform cells, with a high rate of atypical mitotic figures. (A) Intraluminal tumor growth of a leiomyosarcoma originating from the splenic vein (hematoxylin and eosin stain, ×40 magnification). (B) Hematoxylin and eosin stain (×200 magnification) revealed predominantly fusiform cells, with a high rate of atypical mitotic figures.
Figure 4
Figure 4
The tumor cells stained strongly positive for smooth muscle actin (100×).
See this image and copyright information in PMC

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